Acetyl chloride → 2'-Iodoacetanilide

HRID 1092412ノート

反応式

HRID 1092412 の反応式
[I:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[C:9](Cl)(=[O:11])[CH3:10]>N1C=CC=CC=1.Cl>[I:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH:4][C:9](=[O:11])[CH3:10]

参加物

5

反応物 2

HCID 6367Acetyl chlorideHCID 119952-Iodoaniline

生成物 1

HCID 1405592'-Iodoacetanilide

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 1049Pyridine溶媒

反応条件

温度
0 °C

実験手順

2-Iodoaniline (1.00 g, 4.56 mmol) was dissolved in pyridine (5 mL) and cooled to 0° C. After acetyl chloride (314 μL, 5.94 mmol) was added, the reaction was stirred at 0° C. for 1 hour and then at room temperature for 2 hours. The reaction was diluted with 1 N HCl and extracted with ether. The organic layer was dried (MgSO4) and concentrated to give the desired acetamide (assumed quantitative), which was used in the next reaction without further purification.

後処理

  1. waitat room temperature for 2 hours
  2. extractionextracted with ether
  3. dry with materialThe organic layer was dried (MgSO4)
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-57a8314e94374a3bac43794109d4db44
出典データセット
uspto-grants-2012_03
特許番号
US08129424B2

反応ノート

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