N,N-Dimethyl-1,3-propanediamine → HCID 59355218、化合物

HRID 1092646ノート

反応式

HRID 1092646 の反応式
[CH3:1][CH:2]1[CH2:7][CH:6]([CH3:8])[CH2:5][N:4]([S:9]([C:12]2[CH:25]=[CH:24][C:23]3[N:22]([CH3:26])[C:21]4[C:16](=[CH:17][C:18]([S:27]([N:30]5[CH2:35][CH:34]([CH3:36])[CH2:33][CH:32]([CH3:37])[CH2:31]5)(=[O:29])=[O:28])=[CH:19][CH:20]=4)[C:15](=S)[C:14]=3[CH:13]=2)(=[O:11])=[O:10])[CH2:3]1.[CH3:39][N:40]([CH2:42][CH2:43][CH2:44][NH2:45])[CH3:41]>N1C=CC=CC=1>[CH3:36][CH:34]1[CH2:33][CH:32]([CH3:37])[CH2:31][N:30]([S:27]([C:18]2[CH:19]=[CH:20][C:21]3[N:22]([CH3:26])[C:23]4[C:14](=[CH:13][C:12]([S:9]([N:4]5[CH2:3][CH:2]([CH3:1])[CH2:7][CH:6]([CH3:8])[CH2:5]5)(=[O:11])=[O:10])=[CH:25][CH:24]=4)[C:15](=[N:45][CH2:44][CH2:43][CH2:42][N:40]([CH3:41])[CH3:39])[C:16]=3[CH:17]=2)(=[O:28])=[O:29])[CH2:35]1

参加物

4

反応物 2

HCID 7993N,N-Dimethyl-1,3-propanediamineHCID 59355205HCID 59355205、化合物

生成物 1

HCID 59355218HCID 59355218、化合物収率 85.1%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
100 °C

実験手順

A mixture of 2,7-bis(3,5-dimethylpiperidin-1-ylsulfonyl)-10-methylacridine-9(10H) thione (145 mg, 0.25 mmole), pyridine (5 mL) and dimethylaminopropylamine (0.125 mL, 1 mmole) was stirred at 100° C. for 4 hrs. Solvent was partially evaporated and reaction product was precipitated by addition of methanol. Precipitate was collected by filtration, washed with methanol and dried to give 137 mg (85%) of the title compound. MS 644 (MH+).

後処理

  1. customSolvent was partially evaporated
  2. customreaction product
  3. customwas precipitated by addition of methanol
  4. filtrationPrecipitate was collected by filtration
  5. washwashed with methanol
  6. customdried

出典と根拠

ORDレコード
ord-77acec1085f44fab8c86f17e4802ebe7
出典データセット
uspto-grants-2012_03
特許番号
US08129519B2

反応ノート

読み込み中…