Nitric Acid → HCID 178526897、化合物

反応式

[Cl:1][C:2]1[NH:3][C:4]([I:8])=[C:5](I)[N:6]=1.S(=O)(=O)(O)O.O.N.[N+:16]([O-])([OH:18])=[O:17]>>[Cl:1][C:2]1[NH:3][C:4]([I:8])=[C:5]([N+:16]([O-:18])=[O:17])[N:6]=1

参加物

反応物 4

HCID 944Nitric Acid

HCID 1118Sulfuric Acid

HCID 12896473Azane;hydrate

HCID 230802602-Chloro-4,5-diiodoimidazole

生成物 1

HCID 178526897HCID 178526897、化合物収率 81.2%

実験手順

2-Chloro-4,5-diiodoimidazole (354 mg) was suspended in concentrated nitric acid (d. 1.42)(5 ml), under ice-cooling, concentrated sulfuric acid (1 ml) was added, and was stirred at a room temperature for 15 hours. Reaction mixture was poured in ice-water, and ammonia water was added to adjust pH 3, the deposited matters were collected by filtration and dried, there was obtained 2-chloro-5-iodo-4-nitroimidazole (222 mg, yield: 81.2%) as yellow solid product.