Nitric Acid → HCID 178526897、化合物

反応式

[Cl:1][C:2]1[NH:3][CH:4]=[C:5]([I:7])[N:6]=1.S(=O)(=O)(O)O.[N+:13]([O-])([OH:15])=[O:14]>>[Cl:1][C:2]1[NH:6][C:5]([I:7])=[C:4]([N+:13]([O-:15])=[O:14])[N:3]=1

参加物

反応物 3

HCID 944Nitric Acid

HCID 1118Sulfuric Acid

HCID 178478366HCID 178478366、化合物

生成物 1

HCID 178526897HCID 178526897、化合物収率 67%

実験手順

2-Chloro-4-iodoimidazole (431 mg) was suspended in concentrated nitric acid (d. 1.38) (2.5 ml), under ice-cooling, concentrated sulfuric acid (2.5 ml) was added, and stirred at a room temperature for 6 hours. Then, the deposited matters were collected by filtration, and dried, there was obtained 2-chloro-5-iodo-4-nitroimidazole (348 mg, yield: 67.0%) as yellow solid product.