1-(3-Nitrophenyl)propan-2-one → HCID 85861734、化合物

HRID 1092982ノート

反応式

HRID 1092982 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][C:11](=[O:13])[CH3:12])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].C1C=C[NH+]=CC=1.[Br:20][Br-]Br>C1COCC1>[Br:20][CH:10]([C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)[C:11](=[O:13])[CH3:12]

参加物

3

反応物 1

HCID 125079341-(3-Nitrophenyl)propan-2-one

生成物 1

HCID 85861734HCID 85861734、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A stirred solution of 3-nitrophenylacetone (2.5 g, 14.0 mmol) in dry THF (50 ml) at room temperature is treated with polymer supported pyridine hydrobromide perbromide (7.0 g, 14.0 mmol) and left to stir overnight. The reaction mixture is then filtered and the solvent removed in vacuo. The residue is purified by chromatography on silica eluting with 1:4 ethyl acetate-hexane to give the titled compound.

後処理

  1. waitleft
  2. filtrationThe reaction mixture is then filtered
  3. customthe solvent removed in vacuo
  4. customThe residue is purified by chromatography on silica eluting with 1:4 ethyl acetate-hexane

出典と根拠

ORDレコード
ord-f67e3f88fc314871a62188dcd41599ea
出典データセット
uspto-grants-2012_03
特許番号
US08129541B2

反応ノート

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