Hydrochloric Acid → 2-(5-Ethyloxazol-2-yl)ethylamine

HRID 1093024ノート

反応式

HRID 1093024 の反応式
C(OC(=O)[NH:10][CH2:11][CH2:12][C:13]1[O:14][C:15]([CH2:18][CH3:19])=[CH:16][N:17]=1)C1C=CC=CC=1.Cl>C(O)C.[Pd]>[CH2:18]([C:15]1[O:14][C:13]([CH2:12][CH2:11][NH2:10])=[N:17][CH:16]=1)[CH3:19]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 57636953Benzyl [2-(5-ethyloxazol-2-yl)ethyl]carbamate

生成物 1

HCID 115428012-(5-Ethyloxazol-2-yl)ethylamine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution of [2-(5-ethyl-oxazol-2-yl)-ethyl]-carbamic acid benzyl ester (step 3) (0.41 g, 1.49 mmol), 2M HCl (0.75 ml) in ethanol (40 ml) is stirred under hydrogen in the presence of 10% Pd on carbon (0.041 g) for 5 hours. The reaction mixture is filtered and concentrated in vacuo to yield the titled compound.

後処理

  1. filtrationThe reaction mixture is filtered
  2. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-5d50e03430434cfa80153d32ed35c776
出典データセット
uspto-grants-2012_03
特許番号
US08129541B2

反応ノート

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