Ammonia → ethyl 4-(2-aminoethyl)-1H-pyrrole-2-carboxylate

HRID 1093981ノート

反応式

HRID 1093981 の反応式
[C:1]([CH2:3][C:4]1[CH:5]=[C:6]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[NH:7][CH:8]=1)#[N:2].N>CO.O=[Pt]=O>[NH2:2][CH2:1][CH2:3][C:4]1[CH:5]=[C:6]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[NH:7][CH:8]=1

参加物

5

反応物 2

HCID 222AmmoniaHCID 66636709Ethyl 4-(cyanomethyl)-1H-pyrrole-2-carboxylate

生成物 1

HCID 66636613ethyl 4-(2-aminoethyl)-1H-pyrrole-2-carboxylate

試薬・触媒・溶媒 2

HCID 887Methanol溶媒2 回HCID 345198Adams' catalyst溶媒

実験手順

To a solution of the product obtained in Step F (7.45 g) in MeOH (1.5 L) there are added 223 ml of a 1.4N solution of NH3 in MeOH and PtO2 (5.2 g). The reaction mixture is placed under an atmosphere of hydrogen and is then stirred for 20 hours at ambient temperature. After filtration and evaporation to dryness, the residue obtained is purified on silica gel (SiO2: gradient CH2Cl2/MeOH with the addition of 1.4N NH3 in the MeOH) to yield the title product which is used directly in the next Step.

後処理

  1. filtrationAfter filtration and evaporation to dryness
  2. customthe residue obtained
  3. customis purified on silica gel (SiO2
  4. additiongradient CH2Cl2/MeOH with the addition of 1.4N NH3 in the MeOH)

出典と根拠

ORDレコード
ord-7f2272440eb442bb912a9b9628640ba4
出典データセット
uspto-grants-2012_03
特許番号
US08133889B2

反応ノート

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