HCID 57426190、化合物 → HCID 57426196、化合物
反応式
[C:1]([CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[N+:13]([O-])=O)[N:6]([CH2:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH:5]=1)#[N:2]>CCO.[Pd]>[NH2:13][C:11]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:12]=1[C:4]([CH2:3][C:1]#[N:2])=[CH:5][N:6]2[CH2:16][C:17]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:18]参加物
4
実験手順
A mixture of tert-butyl [3-(cyanomethyl)-4-nitro-1H-indol-1-yl]acetate (700 mg, 2.22 mmol, described in Intermediate 11) and 10% Pd/C (65 mg) in EtOH (20 mL) was stirred under an atmosphere of hydrogen (ca. 1 atm). After 4 h, the reaction was filtered through a Celite pad and concentrated in vacuo to give the title compound. MS: m/z=286 (M+1).
後処理
- filtrationthe reaction was filtered through a Celite pad
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-615a2055061a450581d17757ec999afa
- 出典データセット
- uspto-grants-2012_03
- 特許番号
- US08133891B2
反応ノート
読み込み中…