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HRID 1094409作成日：2026年10月27日

5,6,7,8-Tetrahydro-2-naphthylamine → (S)-2-(4-Fluoro-phenyl)-2-hydroxy-N-(5,6,7,8-tetrahydro-naphthalen-2-yl)-N-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-acetamide

https://huagongshe.com/reaction/1094409

反応式

関与物質

役割名称HCID仕込み量
反応物5,6,7,8-Tetrahydro-2-naphthylamineHCID 75193—
反応物2-(4-Fluorophenyl)-2-oxoacetic AcidHCID 579440—
反応物3-Pyridineacetonitrile, 6-(trifluoromethyl)-HCID 50851127—
生成物(S)-2-(4-Fluoro-phenyl)-2-hydroxy-N-(5,6,7,8-tetrahydro-naphthalen-2-yl)-N-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-acetamideHCID 44546438—

反応手順

In analogy to example 47 (steps 3 & 4), 5,6,7,8-Tetrahydro-naphthalen-2-ylamine, (6-Trifluoromethyl-pyridin-3-yl)-acetonitrile & (4-Fluoro-phenyl)-oxo-acetic acid were successively coupled then reduced to give after chiral chromatography (+ve rotation) the target compound. MS(m/e): 473.1 [M+H]+.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08133909B2
出典データセットuspto-grants-2012_03
ORD IDord-e3eca01a8f8a4393a9294845399bf821
出典メモuspto-grants-2012_03