Ammonium → 4-chloro-1H-pyrrole-2-carboxamide

HRID 1094874

反応式

HRID 1094874 の反応式
ClC(Cl)(Cl)[C:3]([C:5]1[NH:6][CH:7]=[C:8]([Cl:10])[CH:9]=1)=[O:4].[NH4+:13]>C1COCC1>[Cl:10][C:8]1[CH:9]=[C:5]([C:3]([NH2:13])=[O:4])[NH:6][CH:7]=1

参加物

4

反応物 2

HCID 223AmmoniumHCID 71306882,2,2-trichloro-1-(4-chloro-1H-pyrrol-2-yl)ethan-1-one

生成物 1

HCID 552075774-chloro-1H-pyrrole-2-carboxamide収率 92%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 2,2,2-trichloro-1-(4-chloro-1H-Pyrrol-2-yl)ethanone (14.0 g, 56.7 mmol) in THF (100 mL) was bubbled with ammonium gas for 2 h at room temperature. TLC analysis indicated that there was complete conversion of starting material. The reaction mixture was concentrated in vacuo to yield 7.5 g of the above compound (51.88 mmol, yield 92%). 1H-NMR (Acetone-d6) δ 10.92 (br s, 1H), 7.21 (br s, 1H), 7.02 (s, 1H), 6.84 (s, 1H), 6.57 (br s, 1H).

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-ea773c68d66d43b68f03ceb3da912e31
出典データセット
uspto-grants-2012_03
特許番号
US08133995B2

関連ノート

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