Hydrazine hydrate (1:1) → 2-(3,4-Dichlorophenyl)-4-(1-hydrazinylideneethyl)thiophene-3-ol

HRID 1094926

反応式

HRID 1094926 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[S:10][CH:11]=[C:12]([C:15]([CH3:17])=O)[C:13]=2[OH:14])[CH:5]=[CH:6][C:7]=1[Cl:8].O.[NH2:19][NH2:20]>C(O)(C)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[S:10][CH:11]=[C:12]([C:15](=[N:19][NH2:20])[CH3:17])[C:13]=2[OH:14])[CH:5]=[CH:6][C:7]=1[Cl:8]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 442072882-(3,4-Dichlorophenyl)-3-hydroxy-4-(methylcarbonyl)thiophene

生成物 1

HCID 714052582-(3,4-Dichlorophenyl)-4-(1-hydrazinylideneethyl)thiophene-3-ol収率 70.3%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

2-(3,4-Dichlorophenyl)-3-hydroxy-4-(methylcarbonyl)thiophene (50 mg, 0.17 mmol) (prepared by the method disclosed in WO2004/108683) in isopropanol was stirred with hydrazine monohydrate (95 μL/0.19 mmol) at 90° C. for 1 hour, then allowed to cool to room temperature and stirred at 0° C. The precipitated solid was collected by filtration and dried to give 36 mg of the desired product (yield 69%).

後処理

  1. filtrationThe precipitated solid was collected by filtration
  2. customdried

出典と根拠

ORDレコード
ord-752470aa96ce4b88b281b4c65b5abb62
出典データセット
uspto-grants-2012_03
特許番号
US08134013B2

関連ノート

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