Pyrrolidine → (3-Bromobenzoyl)pyrrolidine
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5](Cl)=[O:6].[NH:11]1[CH2:15][CH2:14][CH2:13][CH2:12]1>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]([C:5]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[O:6])[CH:8]=[CH:9][CH:10]=1参加物
4
実験手順
A solution of 3-bromo-benzoyl chloride (2.7 g, 12 mmol) in DCM (40 mL) was chilled to zero degrees and treated with pyrrolidine (3 mL, 36.8 mmol). Reaction was allowed to come to room temperature and stir for 4 h. Mixture was then poured onto water and washed once. Organic phase then washed with brine, dried over sodium sulfate, filtered and evaporated to amber oil (3.1 g, 100%).
後処理
- customReaction
- customto come to room temperature
- additionMixture was then poured onto water
- washwashed once
- washOrganic phase then washed with brine
- dry with materialdried over sodium sulfate
- filtrationfiltered
- customevaporated to amber oil (3.1 g, 100%)
出典と根拠
- ORDレコード
- ord-4fba56b3143740a9a365abd569e476c4
- 出典データセット
- uspto-grants-2012_03
- 特許番号
- US08133900B2
反応ノート
読み込み中…