(4-Hydroxyphenoxy)acetic acid → 4-(2-Hydroxyethoxy)phenol
反応式
[OH:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8](O)=[O:9])=[CH:4][CH:3]=1.O1CCCC1.B>O1CCCC1>[OH:9][CH2:8][CH2:7][O:6][C:5]1[CH:11]=[CH:12][C:2]([OH:1])=[CH:3][CH:4]=1参加物
4
実験手順
To a solution of 4-hydroxyphenoxyacetic acid (4.9 g, 29 mmol) (Aldrich) in anhydrous tetrahydrofuran (30 mL) at 0° C. was added borane tetrahydrofuran (1 M, 90 mL, 90 mmol) dropwise. The reaction mixture was then stirred at room temperature for 2 h. The mixture was concentrated and residue was partitioned between ethyl acetate and water. Organic layer was separated, washed with brine, dried over MgSO4, and concentrated to give title compound as a yellow oil (4.2 g, 94%)
後処理
- concentrationThe mixture was concentrated
- customresidue was partitioned between ethyl acetate and water
- customOrganic layer was separated
- washwashed with brine
- dry with materialdried over MgSO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-a4c573d633b54cccb6a1d78c5d7a90c8
- 出典データセット
- uspto-grants-2012_03
- 特許番号
- US08134001B2
反応ノート
読み込み中…