Ethyl 4-(2-nitrophenyl)-3-oxobutanoate → Ethyl 2-(1H-indol-2-yl)acetate
反応式
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][C:11](=O)[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])([O-])=O>[Pd].C(O)C>[NH:1]1[C:4]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:10]=[C:11]1[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14]参加物
4
実験手順
A mixture of ethyl 4-(2-nitrophenyl)-3-oxobutanoate (17.04 g, 67.8 mmol), 10% palladium on carbon (3.6 g), and ethanol (280 mL) was placed under hydrogen pressure (50 psi, 3.4×105 Pa) on a Parr apparatus for 96 hours. The reaction mixture was filtered through a layer of CELITE filter aid. The filtrate was concentrated under reduced pressure to provide crude ethyl 1H-indol-2-ylacetate.
後処理
- customfor 96 hours
- filtrationThe reaction mixture was filtered through a layer of CELITE
- filtrationfilter aid
- concentrationThe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-dbb57773530b44718d2e39d4a90795f6
- 出典データセット
- uspto-grants-2012_03
- 特許番号
- US08138173B2
反応ノート
読み込み中…