Tryptamine → N-Acetyltryptamine

HRID 1095501

反応式

HRID 1095501 の反応式
[NH2:1][CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.C(N(CC)CC)C.[C:20](OC(=O)C)(=[O:22])[CH3:21]>C1COCC1>[NH:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:4]([CH2:3][CH2:2][NH:1][C:20](=[O:22])[CH3:21])=[CH:5]1

参加物

5

反応物 3

HCID 1150TryptamineHCID 7918Acetic AnhydrideHCID 8471Triethylamine

生成物 1

HCID 70547N-Acetyltryptamine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Tryptamine (192 mg/1.2 mmol) was initially introduced into abs. THF (5 ml), and triethylamine (179 μl/1.3 mmol) was added. Acetic anhydride (132 mg/1.3 mmol) was then added and the mixture was stirred at RT for 4 h. The mixture was concentrated to dryness i. vac. The residue was taken up in ethyl acetate and this solution was washed with saturated NaHCO3 solution (two times 20 ml) and with NaCl solution (two times 20 ml). The organic phase was dried over Na2SO4 and concentrated i. vac.

後処理

  1. concentrationThe mixture was concentrated to dryness i
  2. washthis solution was washed with saturated NaHCO3 solution (two times 20 ml) and with NaCl solution (two times 20 ml)
  3. dry with materialThe organic phase was dried over Na2SO4
  4. concentrationconcentrated i

出典と根拠

ORDレコード
ord-2ce0a80823754975b947e0a7fceb9774
出典データセット
uspto-grants-2012_03
特許番号
US08138187B2

関連ノート

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