Pyrrolidine → Pyr-T

HRID 1095532

反応式

HRID 1095532 の反応式
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.Br[CH2:7][CH2:8][C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[NH:11][CH:10]=1>O1CCOCC1>[N:1]1([CH2:7][CH2:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[NH:11][CH:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 31268PyrrolidineHCID 769243-(2-Bromoethyl)indole

生成物 1

HCID 26393Pyr-T

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

反応条件

温度
70 °C

実験手順

Pyrrolidine (3.17 g, 3.7 ml, 44.6 mmol) was dissolved in abs. dioxane (100 ml), 3-(2-bromo-ethyl)-1H-indole (5 g, 22.3 mmol) was added at RT and the mixture was stirred at 70° C. for 8 h. The solution was concentrated, the residue was taken up in CHCl3 (150 ml) and the mixture was washed with water (2×50 ml). The organic phase was dried over Na2SO4, filtered and concentrated i. vac.

後処理

  1. concentrationThe solution was concentrated
  2. washthe mixture was washed with water (2×50 ml)
  3. dry with materialThe organic phase was dried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated i

出典と根拠

ORDレコード
ord-58b2bc03adfe4abaa198417af802bb37
出典データセット
uspto-grants-2012_03
特許番号
US08138187B2

関連ノート

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