関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Morpholine | HCID 8083 | — |
| 反応物 | 3-(2-Bromoethyl)indole | HCID 76924 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 4-(2-(1H-Indol-3-yl)ethyl)morpholine | HCID 213527 | — |
反応手順
Morpholine (2.33 g, 2.33 ml, 26.8 mmol) was dissolved in abs. dioxane (50 ml), and 3-(2-bromo-ethyl)-1H-indole (3.00 g, 13.4 mmol) was added at RT. The solution was stirred at 70° C. for 14 h and concentrated i. vac., the residue was taken up in CHCl3 (100 ml) and the mixture was washed with water (2×30 ml). The organic phase was dried over Na2SO4, filtered and concentrated i. vac. The residue obtained was recrystallized from aqueous methanol.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08138187B2 |
|---|
| 出典データセット | uspto-grants-2012_03 |
|---|
| ORD ID | ord-4845a4d355434365aab47625494f14fb |
|---|
| 出典メモ | uspto-grants-2012_03 |
|---|
