反应详情

温度

70 °C

Morpholine (2.33 g, 2.33 ml, 26.8 mmol) was dissolved in abs. dioxane (50 ml), and 3-(2-bromo-ethyl)-1H-indole (3.00 g, 13.4 mmol) was added at RT. The solution was stirred at 70° C. for 14 h and concentrated i. vac., the residue was taken up in CHCl3 (100 ml) and the mixture was washed with water (2×30 ml). The organic phase was dried over Na2SO4, filtered and concentrated i. vac. The residue obtained was recrystallized from aqueous methanol.

1. concentrationconcentrated i
2. washthe mixture was washed with water (2×30 ml)
3. dry with materialThe organic phase was dried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated i
6. customThe residue obtained
7. customwas recrystallized from aqueous methanol