Tryptamine → Tryptamide

HRID 1095550

反応式

HRID 1095550 の反応式
[NH2:1][CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.Cl.[C:14](Cl)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[N:17][CH:16]=1>C1COCC1>[NH:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:4]([CH2:3][CH2:2][NH:1][C:14](=[O:21])[C:15]2[CH:20]=[CH:19][CH:18]=[N:17][CH:16]=2)=[CH:5]1

参加物

4

反応物 2

HCID 1150TryptamineHCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)

生成物 1

HCID 65768Tryptamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Tryptamine (640 mg, 4.0 mmol) was initially introduced into abs. THF (30 ml). TEA (596 μl, 4.3 mmol) and nicotinic acid chloride hydrochloride (770 mg, 4.3 mmol) was then added and the mixture was stirred at RT for 5 h. The mixture was concentrated to dryness i. vac. The residue was taken up in EA (20 ml) and the mixture was washed with saturated NaHCO3 solution (2×20 ml) and with NaCl solution (2×20 ml). The organic phase was dried over Na2SO4 and concentrated i. vac. Yield: 482 mg (45%)

後処理

  1. concentrationThe mixture was concentrated to dryness i
  2. washthe mixture was washed with saturated NaHCO3 solution (2×20 ml) and with NaCl solution (2×20 ml)
  3. dry with materialThe organic phase was dried over Na2SO4
  4. concentrationconcentrated i

出典と根拠

ORDレコード
ord-84a9b1ea3e754e9fb269f3e7044c6d71
出典データセット
uspto-grants-2012_03
特許番号
US08138187B2

関連ノート

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