HCID 57475161、化合物 → 1-Butyl-4-(5-methoxy-3-methyl-1H-indol-2-yl)-N,N-dimethylcyclohexanamine

HRID 1095561ノート

反応式

HRID 1095561 の反応式
[CH2:1]([C:5]1([N:23]([CH3:25])[CH3:24])[CH2:10][CH2:9][C:8]([C:11]2[NH:12][C:13]3[C:18]([C:19]=2[CH3:20])=[CH:17][C:16]([O:21][CH3:22])=[CH:15][CH:14]=3)=[CH:7][CH2:6]1)[CH2:2][CH2:3][CH3:4]>Br.CCO>[CH2:1]([C:5]1([N:23]([CH3:24])[CH3:25])[CH2:10][CH2:9][CH:8]([C:11]2[NH:12][C:13]3[C:18]([C:19]=2[CH3:20])=[CH:17][C:16]([O:21][CH3:22])=[CH:15][CH:14]=3)[CH2:7][CH2:6]1)[CH2:2][CH2:3][CH3:4]

参加物

4

反応物 1

HCID 57475161HCID 57475161、化合物

生成物 1

HCID 667827291-Butyl-4-(5-methoxy-3-methyl-1H-indol-2-yl)-N,N-dimethylcyclohexanamine

試薬・触媒・溶媒 2

HCID 260Hydrogen Bromide溶媒HCID 702Ethanol溶媒

実験手順

(±)-N-[1-Butyl-4-(5-methoxy-3-methyl-1H-indol-2-yl)cyclohex-3-enyl]-N,N-dimethylamine (1.5 g, 4.4 mmol) was suspended in HBr/glacial acetic acid (33% HBr, 20 ml). Sn powder (2.6 g, 22 mmol) was then added to the mixture in portions at RT in the course of 30 min. When the addition had ended, the reaction mixture was stirred at RT for a further 24 h.—For working up, the mixture was diluted with EtOH (20 ml) and concentrated to dryness on a rotary evaporator. The residue which remained was rendered basic by addition of 5 N NaOH (100 ml). The aqueous mixture obtained was extracted with methylene chloride (4×20 ml). The combined organic phases were washed with water (50 ml), dried over Na2SO4 and then concentrated. The residue obtained (1.5 g) was purified by column chromatography [silica gel 60 (70 g); EtOAc (400 ml), methanol (400 ml)]. 1-Butyl-4-(5-methoxy-3-methyl-1H-indol-2-yl)-N,N-dimethylcyclohexanamine (less polar diastereomer) was obtained in a yield of 141 mg (10%) as a brown oil. The more polar product had to be purified by a second column chromatography [silica gel 60 (50 g); methanol (200 ml), MeCN/methanol/1 M NH4Cl soln. 9:1:1, (250 ml)]. It was obtained in a yield of 125 mg (8%) as a yellow oil.

後処理

  1. additionWhen the addition
  2. concentrationconcentrated to dryness on a rotary evaporator
  3. additionThe residue which remained was rendered basic by addition of 5 N NaOH (100 ml)
  4. customThe aqueous mixture obtained
  5. extractionwas extracted with methylene chloride (4×20 ml)
  6. washThe combined organic phases were washed with water (50 ml)
  7. dry with materialdried over Na2SO4
  8. concentrationconcentrated
  9. customThe residue obtained (1.5 g)
  10. customwas purified by column chromatography [silica gel 60 (70 g); EtOAc (400 ml), methanol (400 ml)]

出典と根拠

ORDレコード
ord-ace21224db5f45e0a70f5dfbc5966b09
出典データセット
uspto-grants-2012_03
特許番号
US08138187B2

反応ノート

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