Phosgene → (Naphthalen-2-yl)methyl carbonochloridate

HRID 1095711

反応式

HRID 1095711 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][OH:12].[C:13](Cl)([Cl:15])=[O:14]>C1COCC1>[C:13]([Cl:15])(=[O:14])[O:12][CH2:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1

参加物

4

反応物 2

HCID 6371PhosgeneHCID 741282-Naphthalenemethanol

生成物 1

HCID 15764399(Naphthalen-2-yl)methyl carbonochloridate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of naphthalen-2-yl methanol (51.2 g, 324 mmol) dissolved in anhydrous THF (1 L) was treated with phosgene (205 mL, 20% solution in toluene, 388 mmol). The solution was stirred at ambient temperature for 45 minutes and then concentrated to afford the desired product as a solid, which was dried under vacuum and used directly in the next step.

後処理

  1. concentrationconcentrated

出典と根拠

ORDレコード
ord-d96c52ce10ba4d25878f4c585d9b5ae9
出典データセット
uspto-grants-2012_03
特許番号
US08138181B2

関連ノート

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