Ammonium Chloride → 1-Methoxy-2-phenyl-pent-4-en-2-ol

HRID 1096312

反応式

HRID 1096312 の反応式
[CH3:1][O:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[CH2:12]([Mg]Cl)[CH:13]=[CH2:14].[NH4+].[Cl-]>O1CCCC1>[CH3:1][O:2][CH2:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)([OH:5])[CH2:14][CH:13]=[CH2:12]

参加物

5

反応物 3

HCID 25517Ammonium ChlorideHCID 776982-Methoxy-1-phenylethanoneHCID 178418473HCID 178418473、化合物

生成物 1

HCID 596356791-Methoxy-2-phenyl-pent-4-en-2-ol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

2-Methoxy-1-phenyl-ethanone (5.00 g) dissolved in tetrahydrofuran (50 mL) was added to 2 M allylmagnesium chloride in tetrahydrofuran (21 mL) at room temperature. The solution was stirred at room temperature for 3 h and then 10% aqueous NH4Cl solution (50 mL) was added. The resulting mixture was extracted with tert-butyl methyl ether (3×50 mL) and the combined extracts were washed with water (50 mL) and brine (50 mL). The solvent was evaporated to afford the title compound as a colorless oil.

後処理

  1. extractionThe resulting mixture was extracted with tert-butyl methyl ether (3×50 mL)
  2. washthe combined extracts were washed with water (50 mL) and brine (50 mL)
  3. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-25896d77513447b38111ccc932944693
出典データセット
uspto-grants-2012_03
特許番号
US08138178B2

関連ノート

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