Sodium borohydride → 2-(Thiazol-2-ylmethoxy)ethanol
反応式
C[O:2][C:3](=O)[CH2:4][O:5][CH2:6][C:7]1[S:8][CH:9]=[CH:10][N:11]=1.[BH4-].[Na+]>CO>[S:8]1[CH:9]=[CH:10][N:11]=[C:7]1[CH2:6][O:5][CH2:4][CH2:3][OH:2]参加物
4
実験手順
A cooled (0° C.) sol. of (thiazol-2-ylmethoxy)acetic acid methyl ester (31.0 g, 165.6 mmol) in MeOH (830 mL) was treated portionwise with NaBH4 (31.0 g, 1.66 mol). The reaction mixture was allowed to warm to rt over 1 h. The mixture was then quenched with water, and extracted with CH2Cl2 (3×). The combined org. layers were dried over MgSO4, filtered, and the solvents were removed under reduced pressure to give the title compound as an orange oil (22.9 g, 87%) that was not further purified. LC-MS: tR=0.44 min, ES+: 160.19.
後処理
- customThe mixture was then quenched with water
- extractionextracted with CH2Cl2 (3×)
- dry with materiallayers were dried over MgSO4
- filtrationfiltered
- customthe solvents were removed under reduced pressure
出典と根拠
- ORDレコード
- ord-e6118091d65542f7b97b4240cc204a09
- 出典データセット
- uspto-grants-2012_03
- 特許番号
- US08138340B2
反応ノート
読み込み中…