2-Methyl-3-(trifluoromethyl)benzyl alcohol → 2-Methyl-3-(trifluoromethyl)benzaldehyde

HRID 1096831ノート

反応式

HRID 1096831 の反応式
[CH3:1][C:2]1[C:9]([C:10]([F:13])([F:12])[F:11])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5]>C(Cl)Cl.O=[Mn]=O>[CH3:1][C:2]1[C:9]([C:10]([F:11])([F:12])[F:13])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:5]

参加物

4

反応物 1

HCID 27756102-Methyl-3-(trifluoromethyl)benzyl alcohol

生成物 1

HCID 37191482-Methyl-3-(trifluoromethyl)benzaldehyde

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 6344Dichloromethane溶媒

実験手順

To a sol. of 2-methyl-3-trifluoromethylbenzyl alcohol (0.500 g, 2.63 mmol) in CH2Cl2 (25 mL) was added activated MnO2 (2.29 g, 26.3 mmol). After stirring for 72 h, the mixture was filtered over Celite, and the solvents were removed under reduced pressure. The aldehyde is used in the next step without further purification. 1H NMR (CDCl3) δ 10.40 (s, 1H), 8.00 (d, 1H), 7.85 (d, 1H), 7.45 (t, 1H), 2.8 (s, 3H).

後処理

  1. filtrationthe mixture was filtered over Celite
  2. customthe solvents were removed under reduced pressure
  3. customThe aldehyde is used in the next step without further purification

出典と根拠

ORDレコード
ord-8d06c68ad251450f9c1b069ecc633508
出典データセット
uspto-grants-2012_03
特許番号
US08138340B2

反応ノート

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