Dimethylformamide → HCID 57930910、化合物

HRID 1096940ノート

反応式

HRID 1096940 の反応式
C(=O)([O-])[O-].[K+].[K+].I[CH2:8][CH3:9].CN(C=O)C.[OH:15][C:16]1[CH:17]=[C:18]([CH:23]=[C:24]([O:26][S:27]([C:30]([F:33])([F:32])[F:31])(=[O:29])=[O:28])[CH:25]=1)[C:19]([O:21][CH3:22])=[O:20]>C(OCC)C>[CH2:8]([O:15][C:16]1[CH:17]=[C:18]([CH:23]=[C:24]([O:26][S:27]([C:30]([F:33])([F:31])[F:32])(=[O:29])=[O:28])[CH:25]=1)[C:19]([O:21][CH3:22])=[O:20])[CH3:9]

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 86635508HCID 86635508、化合物

生成物 1

HCID 57930910HCID 57930910、化合物

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

With cooling with ice, potassium carbonate (152 mg, 1.10 mmol) and iodoethane (0.088 mL, 1.10 mmol) were added to a DMF solution (2.0 mL) of methyl 3-hydroxy-5-trifluoromethane-sulfonyloxybenzoate (300 mg, 1.00 mmol), and stirred at room temperature for 14 hours. The reaction mixture was diluted with diethyl ether (30 mL), then washed with water and aqueous saturated sodium chloride solution, dried with sodium sulfate, and concentrated under reduced pressure. The residue was purified through silica gel column chromatography to obtain the title compound as a colorless oil.

後処理

  1. washwashed with water and aqueous saturated sodium chloride solution
  2. dry with materialdried with sodium sulfate
  3. concentrationconcentrated under reduced pressure
  4. customThe residue was purified through silica gel column chromatography

出典と根拠

ORDレコード
ord-5f2e9731d06c4ea488963e6708c78729
出典データセット
uspto-grants-2012_03
特許番号
US08138197B2

反応ノート

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