Hydrochloric Acid → 3,5-Diethoxy-4-isoxazol-4-yl-benzoic acid

HRID 1096991ノート

反応式

HRID 1096991 の反応式
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:11]=[C:12]([O:19][CH2:20][CH3:21])[C:13]=1[C:14]1[CH:15]=[N:16][O:17][CH:18]=1)[C:7]([O:9]C)=[O:8])[CH3:2].Cl>CO.C1COCC1.[OH-].[Na+]>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:11]=[C:12]([O:19][CH2:20][CH3:21])[C:13]=1[C:14]1[CH:15]=[N:16][O:17][CH:18]=1)[C:7]([OH:9])=[O:8])[CH3:2]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 57931014Methyl 3,5-diethoxy-4-(isoxazol-4-yl)benzoate

生成物 1

HCID 579309183,5-Diethoxy-4-isoxazol-4-yl-benzoic acid

試薬・触媒・溶媒 2

HCID 14798Sodium Hydroxide溶媒HCID 21899815MeOH tetrahydrofuran溶媒

実験手順

Methyl 3,5-diethoxy-4-(isoxazol-4-yl)benzoate (91 mg) was dissolved in a mixed solvent of methanol/THF (8 mL, 3/5), aqueous 1 M NaOH solution (1.2 mL) was added to it, and stirred at room temperature for 5 hours. Aqueous 1 M HCl solution (1.2 mL) was added to it, and the solvent was concentrated under reduced pressure. The formed solid was taken out through filtration, washed with water, and dried under reduced pressure to obtain the title compound as a pale yellow solid.

後処理

  1. additionwas added to it
  2. concentrationthe solvent was concentrated under reduced pressure
  3. filtrationThe formed solid was taken out through filtration
  4. washwashed with water
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-553a18b38cc445e484a6466a8808f0a3
出典データセット
uspto-grants-2012_03
特許番号
US08138197B2

反応ノート

読み込み中…