Ethanol → 3-Amino-5-phenylselenophene-2-carboxamide

HRID 1097221ノート

反応式

HRID 1097221 の反応式
[NH2:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[Se:4][C:3]=1[C:13]#[N:14].C([OH:17])C>[OH-].[Na+]>[NH2:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[Se:4][C:3]=1[C:13]([NH2:14])=[O:17]

参加物

4

反応物 2

HCID 702EthanolHCID 866468883-Amino-5-phenylselenophene-2-carbonitrile

生成物 1

HCID 866468873-Amino-5-phenylselenophene-2-carboxamide収率 67%

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

To a suspension of 3-amino-5-phenylselenophene-2-carbonitrile (4.0 g) in aqueous sodium hydroxide solution (120 mL, 10%) was added ethanol (50 mL) and the mixture refluxed for 45 min. The mixture was allowed to rt and the crystals separated were filtered off, washed with cold water and dried to give the product as golden yellow color solid (2.8 g, 67%), mp 184-186° C. 1H NMR (400 MHz, CDCl3): δ 7.50-7.53 (2H, m, Ar—H), 7.36-7.38 (3H, m, Ar—H), 7.04 (1H, s, H-4), 5.84 (2H, br s, —CONH2), 5.12 (2H, br s, —NH2).

後処理

  1. temperaturethe mixture refluxed for 45 min
  2. customwas allowed to rt
  3. customthe crystals separated
  4. filtrationwere filtered off
  5. washwashed with cold water
  6. customdried

出典と根拠

ORDレコード
ord-9cb451e22a274ff2879b31780753d8a2
出典データセット
uspto-grants-2012_03
特許番号
US08143237B2

反応ノート

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