Hydrochloric Acid → (2E)-3-(1,3,3-Trimethyl-2-oxo-2,3-dihydro-1H-indol-7-yl)acrylic acid

HRID 1097438ノート

反応式

HRID 1097438 の反応式
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2/[CH:11]=[CH:12]/[C:13]([O:15]CC)=[O:14])[C:4]([CH3:19])([CH3:18])[C:3]1=[O:20].[OH-].[Na+].Cl>CO>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2/[CH:11]=[CH:12]/[C:13]([OH:15])=[O:14])[C:4]([CH3:18])([CH3:19])[C:3]1=[O:20]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 66812761Ethyl (2E)-3-(1,3,3-trimethyl-2-oxo-2,3-dihydro-1H-indol-7-yl)acrylate

生成物 1

HCID 59322842(2E)-3-(1,3,3-Trimethyl-2-oxo-2,3-dihydro-1H-indol-7-yl)acrylic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of ethyl (2E)-3-(1,3,3-trimethyl-2-oxo-2,3-dihydro-1H-indol-7-yl)acrylate (25 mg, 0.091 mmol) in MeOH (1 mL) was added 1 N aqueous NaOH (0.1 mL) and the resulting mixture was stirred at ambient temperature for 18 h. To the reaction mixture was added 1 N aqueous HCl (0.1 mL) and the resulting mixture was concentrated to dryness under reduced pressure to give the title compound. MS: m/z=246 (M+1).

後処理

  1. concentrationthe resulting mixture was concentrated to dryness under reduced pressure

出典と根拠

ORDレコード
ord-664873fb9f5940c4a2761d4143789d53
出典データセット
uspto-grants-2012_03
特許番号
US08143266B2

反応ノート

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