6-allyl-3-benzyloxycarbonylamino-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic Acid → benzyl N-[6-[[4-[N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]phenyl]methylcarbamoyl]-4-oxo-6-prop-2-enyl-7,8-dihydropyrrolo[1,2-a]pyrimidin-3-yl]carbamate

HRID 10976

反応式

HRID 10976 の反応式
[CH2:1]([C:4]1([C:25](O)=[O:26])[N:8]2[C:9](=[O:24])[C:10]([NH:13][C:14]([O:16][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[O:15])=[CH:11][N:12]=[C:7]2[CH2:6][CH2:5]1)[CH:2]=[CH2:3].[C:28]([O:32][C:33](=[O:45])[NH:34][C:35]([C:37]1[CH:42]=[CH:41][C:40]([CH2:43][NH2:44])=[CH:39][CH:38]=1)=[NH:36])([CH3:31])([CH3:30])[CH3:29]>>[CH2:17]([O:16][C:14](=[O:15])[NH:13][C:10]1[C:9](=[O:24])[N:8]2[C:4]([CH2:1][CH:2]=[CH2:3])([C:25](=[O:26])[NH:44][CH2:43][C:40]3[CH:39]=[CH:38][C:37]([C:35]([NH:34][C:33]([O:32][C:28]([CH3:31])([CH3:29])[CH3:30])=[O:45])=[NH:36])=[CH:42][CH:41]=3)[CH2:5][CH2:6][C:7]2=[N:12][CH:11]=1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

参加物

3

反応物 2

HCID 219796976-allyl-3-benzyloxycarbonylamino-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic AcidHCID 145832046tert-butyl N-[4-(aminomethyl)benzenecarboximidoyl]carbamate

生成物 1

HCID 145857203benzyl N-[6-[[4-[N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]phenyl]methylcarbamoyl]-4-oxo-6-prop-2-enyl-7,8-dihydropyrrolo[1,2-a]pyrimidin-3-yl]carbamate収率 86%

実験手順

According to the procedure for the preparation of intermediate 19c, intermediate 20b (50 mg, 0.135 mmol) was coupled with [(4-aminomethyl-phenyl)-imino-methyl]-carbamic acid tert-butyl ester to afford 70 mg (86%) of intermediate 20c.

出典と根拠

ORDレコード
ord-1f57f987a2284ab48972c433a6c34bef
出典データセット
uspto-grants-2006_08
特許番号
US07094783B2

関連ノート

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