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6-allyl-3-benzyloxycarbonylamino-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic Acid → benzyl N-[6-[[4-[N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]phenyl]methylcarbamoyl]-4-oxo-6-prop-2-enyl-7,8-dihydropyrrolo[1,2-a]pyrimidin-3-yl]carbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-allyl-3-benzyloxycarbonylamino-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic Acid | HCID 21979697 | — |
| 反応物 | tert-butyl N-[4-(aminomethyl)benzenecarboximidoyl]carbamate | HCID 145832046 | — |
| 生成物 | benzyl N-[6-[[4-[N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]phenyl]methylcarbamoyl]-4-oxo-6-prop-2-enyl-7,8-dihydropyrrolo[1,2-a]pyrimidin-3-yl]carbamate | HCID 145857203 | 86% |
反応手順
According to the procedure for the preparation of intermediate 19c, intermediate 20b (50 mg, 0.135 mmol) was coupled with [(4-aminomethyl-phenyl)-imino-methyl]-carbamic acid tert-butyl ester to afford 70 mg (86%) of intermediate 20c.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07094783B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-1f57f987a2284ab48972c433a6c34bef |
| 出典メモ | uspto-grants-2006_08 |