Water → HCID 178513306、化合物

HRID 1097699ノート

反応式

HRID 1097699 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]#[N:8].C(=O)([O-])[O-].[K+].[K+].[OH2:15].Cl.[NH2:17]O>CCO>[OH:15][NH:8][C:7]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)=[NH:17]

参加物

6

反応物 4

HCID 962WaterHCID 7522Pyridine-2-carbonitrileHCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochloride

生成物 1

HCID 178513306HCID 178513306、化合物収率 57%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a mixture of 2-pyridinecarbonitrile (3 g, 29 mmol) and potassium carbonate (4.1 g, 30 mmol) in EtOH (30 ml) was added water (15 ml) and, cautiously, hydroxylamine hydrochloride (2.9 g, 42 mmol) and then heated at reflux for 6 h, cooled and evaporated to dryness. The residue was treated with water (100 ml) and the suspended solid product filtered off, washed with water and dried to yield the title compound as a white solid (2.28 g, 57%).

後処理

  1. temperatureat reflux for 6 h
  2. temperaturecooled
  3. customevaporated to dryness
  4. additionThe residue was treated with water (100 ml)
  5. filtrationthe suspended solid product filtered off
  6. washwashed with water
  7. customdried

出典と根拠

ORDレコード
ord-a94e094ee67548509da3f39dbe15a321
出典データセット
uspto-grants-2012_03
特許番号
US08143264B2

反応ノート

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