Sodium borohydride → HCID 59277703、化合物

HRID 1097775ノート

反応式

HRID 1097775 の反応式
[BH4-].[Na+].[CH3:3][N:4]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[C:7](=[O:14])[C:6]([CH3:16])([CH3:15])[S:5]1(=[O:18])=[O:17]>CCO>[CH3:3][N:4]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[CH:7]([OH:14])[C:6]([CH3:16])([CH3:15])[S:5]1(=[O:17])=[O:18]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 59277705HCID 59277705、化合物

生成物 1

HCID 59277703HCID 59277703、化合物収率 100%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

NaBH4 (45 mg, 1.2 mmol) is added to a solution of 1,3,3-Trimethyl-2,2-dioxo-2,3-dihydro-1H-benzo[c][1,2]thiazin-4-one (190 mg, 0.8 mmol) in 15 mL of EtOH at 0° C. The resulting mixture is stirred at this temperature for overnight. The reaction is quenched by HCl (1M), and extracted with ethyl acetate (15 mL×3). The combined extracts are dried over anhydrous Na2SO4. After filtration and concentration, the residue is purified by flash column and yields the title compound as oil (193 mg).

後処理

  1. customThe reaction is quenched by HCl (1M)
  2. extractionextracted with ethyl acetate (15 mL×3)
  3. dry with materialThe combined extracts are dried over anhydrous Na2SO4
  4. filtrationAfter filtration and concentration
  5. customthe residue is purified by flash column

出典と根拠

ORDレコード
ord-20043f9432974a28b0460af2f9fb8491
出典データセット
uspto-grants-2012_03
特許番号
US08143278B2

反応ノート

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