Hydrazine hydrate (1:1) → 2-Hydrazinyl-3-methylpyrazine
反応式
O.[NH2:2][NH2:3].Cl[C:5]1[C:10]([CH3:11])=[N:9][CH:8]=[CH:7][N:6]=1>C(O)C>[NH:2]([C:5]1[C:10]([CH3:11])=[N:9][CH:8]=[CH:7][N:6]=1)[NH2:3]参加物
4
反応条件
- 温度
- 90 °C
実験手順
Hydrazine hydrate (9.66 mL, 311.14 mmol) was added to 2-chloro-3-methylpyrazine (CAS no. 95-58-9) (8 g, 62.23 mmol) in ethanol (25 mL). The resulting solution was stirred at 90° C. for 16 hours. The resulting solution was evaporated to dryness and the crude product was purified by crystallisation from toluene (125 mL) to afford 2-hydrazinyl-3-methylpyrazine (6.2 g, 80%). 1H NMR (400 MHz, DMSO-d6) δ 2.24 (3H, s), 7.61 (1H, d), 7.61 (1H, d), 7.87 (1H, d).
後処理
- customThe resulting solution was evaporated to dryness
- customthe crude product was purified by crystallisation from toluene (125 mL)
出典と根拠
- ORDレコード
- ord-eba063b6363646cba6df39603f4ff3dc
- 出典データセット
- uspto-grants-2012_03
- 特許番号
- US08143263B2
反応ノート
読み込み中…