3-benzyloxycarbonylamino-6-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic Acid → 3-benzyloxycarbonylamino-6-methoxymethyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic Acid

HRID 10984

反応式

HRID 10984 の反応式
C(OC(NC1C(=O)N2C(C)(C(O)=O)CCC2=NC=1)=O)C1C=CC=CC=1.C([O:30][C:31]([C:33]1([CH2:54][O:55][CH3:56])[N:37]2[C:38](=[O:53])[C:39]([NH:42][C:43]([O:45][CH2:46][C:47]3[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=3)=[O:44])=[CH:40][N:41]=[C:36]2[CH2:35][CH2:34]1)=[O:32])(C)(C)C>>[CH2:46]([O:45][C:43]([NH:42][C:39]1[C:38](=[O:53])[N:37]2[C:33]([CH2:54][O:55][CH3:56])([C:31]([OH:32])=[O:30])[CH2:34][CH2:35][C:36]2=[N:41][CH:40]=1)=[O:44])[C:47]1[CH:52]=[CH:51][CH:50]=[CH:49][CH:48]=1

参加物

3

反応物 2

HCID 219796983-benzyloxycarbonylamino-6-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic AcidHCID 696005813-benzyloxycarbonylamino-6-methoxymethyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic Acid tert-butyl Ester

生成物 1

HCID 219796433-benzyloxycarbonylamino-6-methoxymethyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic Acid

実験手順

According to the procedure for the preparation of intermediate 19b, intermediate 23a (87 mg, 0.203 mmol) was deprotected to afford 76 mg (quantitative) of intermediate 23b. MS (ESI) 418.3 (M 2Na++H+), 372.2 (M−H+).

出典と根拠

ORDレコード
ord-96eaada888e34835aeae2998f8196457
出典データセット
uspto-grants-2006_08
特許番号
US07094783B2

関連ノート

読み込み中…