Lithium Hydroxide → 5-methyl-1-(propan-2-yl)-1H-pyrazole-4-carboxylic acid

反応式

[CH:1]([N:4]1[C:8]([CH3:9])=[C:7]([C:10]([O:12]CC)=[O:11])[CH:6]=[N:5]1)([CH3:3])[CH3:2].[OH-].[Li+]>>[CH:1]([N:4]1[C:8]([CH3:9])=[C:7]([C:10]([OH:12])=[O:11])[CH:6]=[N:5]1)([CH3:3])[CH3:2]

参加物

反応物 2

HCID 3939Lithium Hydroxide

HCID 59734395HCID 59734395、化合物

生成物 1

HCID 230056715-methyl-1-(propan-2-yl)-1H-pyrazole-4-carboxylic acid収率 70%

実験手順

In a procedure analogous to Example B6, ethyl 1-isopropyl-5-methyl-1H-pyrazole-4-carboxylate (537 mg, 2.74 mmol) and lithium hydroxide (459 mg, 10.95 mmol) were combined to give 1-isopropyl-5-methyl-1H-pyrazole-4-carboxylic acid (32 mg, 70% yield) as an off white solid. MS (ESI) m/z: 169.0 (M+H+).

出典と根拠

ORDレコード: ord-ed8bf95c61ac41e68dacb6720808edbe
出典データセット: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08143293B2

反応ノート

読み込み中…

参加物