HCID 66728944、化合物 → 5-(Propan-2-yl)pyridin-3-amine

HRID 1098579ノート

反応式

HRID 1098579 の反応式
[CH2:1]=[C:2]([C:4]1[CH:5]=[C:6]([NH2:10])[CH:7]=[N:8][CH:9]=1)[CH3:3]>C(O)C.[Pd]>[CH:2]([C:4]1[CH:5]=[C:6]([NH2:10])[CH:7]=[N:8][CH:9]=1)([CH3:3])[CH3:1]

参加物

4

反応物 1

HCID 66728944HCID 66728944、化合物

生成物 1

HCID 591352765-(Propan-2-yl)pyridin-3-amine収率 134.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of 5-(prop-1-en-2-yl)pyridin-3-amine (0.773 g, 2.48 mmol) in ethanol (8 mL) was added 10% Pd/C (0.132 g, 0.124 mmol) and the resulting suspension was stirred under a hydrogen atmosphere (1 atm) for 18 h. The reaction was filtered through Celite® and washed forward with EtOH. The filtrate was concentrated, diluted with EtOAc (30 mL) and washed with H2O (1×15 ml) and brine (1×15 ml). The aqueous phase was back-extracted with EtOAc (1×20 ml). The combined organic layers were dried (MgSO4) and concentrated to afford 5-isopropylpyridin-3-amine (0.453 g, 134%) as a light yellow oil. MS (ESI) m/z: 137.1 (M+H+).

後処理

  1. filtrationThe reaction was filtered through Celite®
  2. washwashed forward with EtOH
  3. concentrationThe filtrate was concentrated
  4. additiondiluted with EtOAc (30 mL)
  5. washwashed with H2O (1×15 ml) and brine (1×15 ml)
  6. extractionThe aqueous phase was back-extracted with EtOAc (1×20 ml)
  7. dry with materialThe combined organic layers were dried (MgSO4)
  8. concentrationconcentrated

出典と根拠

ORDレコード
ord-132e49140dad42fab7c464c6af402992
出典データセット
uspto-grants-2012_03
特許番号
US08143293B2

反応ノート

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