Ammonia → 4-Bromo-2-chlorobenzenesulfonamide
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[C:4]([Cl:12])[CH:3]=1.[NH3:13].C(OCC)(=O)C.O>C1COCC1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:13])(=[O:10])=[O:9])=[C:4]([Cl:12])[CH:3]=1参加物
6
実験手順
To a solution of 4-bromo-2-chlorobenzenesulfonyl chloride (2.50 g, 8.45 mmol) in THF (25 ml) was added a solution of ammonia (25%, 6.3 ml, 84.5 mmol). The reaction mixture was stirred for 4 h at RT. Ethyl acetate (70 ml) and water (50 mL) were added. The organic phase was separated and washed with hydrochloric acid (1 M, 50 ml) and brine (2×30 ml) and dried over sodium sulfate. After evaporation the product was obtained as a white solid (2.05 g, 90%) which was used in the next step without further purification.
後処理
- customThe organic phase was separated
- washwashed with hydrochloric acid (1 M, 50 ml) and brine (2×30 ml)
- dry with materialdried over sodium sulfate
- customAfter evaporation the product
出典と根拠
- ORDレコード
- ord-f8ce2044d6b6470ba4d1e404f4dfdf2e
- 出典データセット
- uspto-grants-2012_03
- 特許番号
- US08143242B2
反応ノート
読み込み中…