Hydrazine hydrate (1:1) → 6-(4-Bromo-3-fluorophenyl)-3-hydrazino-1,2,4-triazine

HRID 1099055ノート

反応式

HRID 1099055 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[N:12][C:11](SC)=[N:10][CH:9]=2)=[CH:4][C:3]=1[F:16].O.[NH2:18][NH2:19]>C(O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[N:12][C:11]([NH:18][NH2:19])=[N:10][CH:9]=2)=[CH:4][C:3]=1[F:16]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 668131126-(4-Bromo-3-fluorophenyl)-3-(methylthio)-1,2,4-triazine

生成物 1

HCID 592163026-(4-Bromo-3-fluorophenyl)-3-hydrazino-1,2,4-triazine収率 77.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
90 °C

実験手順

A mixture of 6-(4-bromo-3-fluorophenyl)-3-(methylthio)-1,2,4-triazine (1.15 g, 0.00383 mol) and hydrazine hydrate (0.74 mL, 0.015 mol) in ethanol (50 mL) was heated at 90° C. for 20 h. After cooling, the formed precipitate was collected by filtration, and dried in-vacuo to afford the desired product (0.845 g, 77.6%).

後処理

  1. temperatureAfter cooling
  2. filtrationthe formed precipitate was collected by filtration
  3. customdried in-vacuo

出典と根拠

ORDレコード
ord-d623b7ae670348988d239b3d7b872548
出典データセット
uspto-grants-2012_03
特許番号
US08143251B2

反応ノート

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