Hydrochloric Acid → (7-Methoxy-1-naphthyl)(oxo)acetic acid

HRID 1099495

反応式

HRID 1099495 の反応式
C1OCCOCCOCCOCCOCC[O:3]C1.[CH3:19][O:20][C:21]1[CH:31]=[CH:30][C:29]2[C:32]3[C:22]=1[C:23](=[O:34])[C:24](=[O:33])[C:25]=3[CH:26]=[CH:27][CH:28]=2.O.Cl>CS(C)=O>[CH3:19][O:20][C:21]1[CH:22]=[C:32]2[C:29]([CH:28]=[CH:27][CH:26]=[C:25]2[C:24](=[O:33])[C:23]([OH:34])=[O:3])=[CH:30][CH:31]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 2855718-Crown-6HCID 22502643-Methoxyacenaphthoquinone

生成物 1

HCID 14462720(7-Methoxy-1-naphthyl)(oxo)acetic acid収率 88%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

In a reactor, 4 mg of 18-crown-6 ether and then 230 mg of NaNH2 are successively introduced into a suspension of 100 mg of 3-methoxyacenaphthoquinone in 1 ml of DMSO. The mixture is stirred for 30 minutes at ambient temperature. Water (2 ml) is then added, followed by 2N HCl solution (3 ml). After two extractions with ethyl acetate, the solvents are dried over Na2SO4 and then evaporated off to yield the title product in the form of a yellow solid in a yield of 88% and with a chemical purity of more than 94%.

後処理

  1. extractionAfter two extractions with ethyl acetate
  2. dry with materialthe solvents are dried over Na2SO4
  3. customevaporated off

出典と根拠

ORDレコード
ord-4a1196c80d5a47079f125b06fd9b6367
出典データセット
uspto-grants-2012_03
特許番号
US08143449B2

関連ノート

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