関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethylene Glycol | HCID 174 | — |
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | (Methyl-phenyl-amino)-acetic acid ethyl ester | HCID 265936 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-Hydroxyethyl N-methyl-N-phenylglycinate | HCID 20554961 | — |
反応手順
Into a 100 ml. flask fitted with a condenser and a Dean-Stark trap there were placed 49.5 gms. ethylene glycol, 17 gms. of ethyl N-methyl-N-phenylglycinate and 0.7 gm. sodium methoxide. The flask and contents were heated to 150° C. in an oil bath and stirred for 13 hours. The reaction mixture was allowed to cool to room temperature and 1.25 ml. of concentrated HCl in 3.5 ml. water were added and the mixture was stirred for 10 minutes. After the ethylene glycol was distilled off at atmospheric pressure, 11.5 gms. of product was obtained by vacuum distillation, b.p. (0.3 mm.) 139°-149° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04310512 |
|---|
| 出典データセット | uspto-grants-1982_01 |
|---|
| ORD ID | ord-a42ba69b9911477aacbdbc293192e764 |
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| 出典メモ | uspto-grants-1982_01 |
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