反应详情

温度

150 °C

Into a 100 ml. flask fitted with a condenser and a Dean-Stark trap there were placed 49.5 gms. ethylene glycol, 17 gms. of ethyl N-methyl-N-phenylglycinate and 0.7 gm. sodium methoxide. The flask and contents were heated to 150° C. in an oil bath and stirred for 13 hours. The reaction mixture was allowed to cool to room temperature and 1.25 ml. of concentrated HCl in 3.5 ml. water were added and the mixture was stirred for 10 minutes. After the ethylene glycol was distilled off at atmospheric pressure, 11.5 gms. of product was obtained by vacuum distillation, b.p. (0.3 mm.) 139°-149° C.

1. customflask fitted with a condenser
2. temperatureto cool to room temperature
3. stirringthe mixture was stirred for 10 minutes
4. distillationAfter the ethylene glycol was distilled off at atmospheric pressure, 11.5 gms
5. customof product was obtained by vacuum distillation, b.p
6. custom(0.3 mm.) 139°-149° C.