Isobutyraldehyde → 3-Ethyl-2-(propan-2-yl)-1,3-oxazolidine

HRID 1106128ノート

反応式

HRID 1106128 の反応式
[CH:1](=[O:5])[CH:2]([CH3:4])[CH3:3].[CH2:6]([NH:8][CH2:9][CH2:10]O)[CH3:7]>C1C=CC=CC=1>[CH:2]([CH:1]1[N:8]([CH2:9][CH3:10])[CH2:6][CH2:7][O:5]1)([CH3:4])[CH3:3]

参加物

4

反応物 2

HCID 6561IsobutyraldehydeHCID 80722-(Ethylamino)ethanol

生成物 1

HCID 2588383-Ethyl-2-(propan-2-yl)-1,3-oxazolidine

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

Iso-butyraldehyde (11.1 g; 0.15 moles) was added slowly over a period of 1 hour to N-ethyl-2-hydroxyethylamine (13.3 g; 0.15 moles) at a temperature of 25°-30° C. Benzene (100 ml) was then added, and the resulting solution was heated to reflux. Continuous azeotropic distillation removed 2.8 ml of water. The benzene was then removed by vacuum distillation to give the desired 2-isopropyl-3-ethyl-1,3-oxazolidine as a yellow liquid.

後処理

  1. temperaturethe resulting solution was heated to reflux
  2. distillationContinuous azeotropic distillation
  3. customremoved 2.8 ml of water
  4. customThe benzene was then removed by vacuum distillation

出典と根拠

ORDレコード
ord-9b4f380f3806411aab25c8692a8df7e9
出典データセット
uspto-grants-1982_01
特許番号
US04311827

反応ノート

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