Imidazole → (+/-) 4-Trimethylsilyloxy-4-n-propyl-1-octyne
反応式
[OH:1][C:2]([CH2:10][CH2:11][CH3:12])([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:3][C:4]#[CH:5].N1C=CN=C1.[CH3:18][Si:19]([CH3:22])([CH3:21])Cl.CCOCC>CN(C)C=O.O>[CH3:18][Si:19]([CH3:22])([CH3:21])[O:1][C:2]([CH2:10][CH2:11][CH3:12])([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:3][C:4]#[CH:5]参加物
7
実験手順
16.8 Grams of 4-hydroxy-4-n-propyl-1-octyne is dissolved in 100 ml of dimethylformamide and treated with 8 g of imidazole and then with 12 g of trimethylchlorosilane. The reaction mixture was stirred at room temperature for 1 hour and then poured into a mixture of ether and water. The organic layer was washed with water 3-4 times, dried over sodium sulfate, and stripped of solvent. Distillation of the residue gave the title product as a colorless liquid.
後処理
- washThe organic layer was washed with water 3-4 times
- dry with materialdried over sodium sulfate
- distillationDistillation of the residue
出典と根拠
- ORDレコード
- ord-362273ef0d074c07bc3b70c8ca2a5215
- 出典データセット
- uspto-grants-1982_01
- 特許番号
- US04312994
反応ノート
読み込み中…