HCID 21253084、化合物 → HCID 21253068、化合物

HRID 1106437ノート

反応式

HRID 1106437 の反応式
[ClH:1].[Br:2][C:3]1[CH:12]=[C:11]([N+:13]([O-])=O)[C:10]([NH2:16])=[C:9]2[C:4]=1[CH2:5][CH2:6][NH:7][CH2:8]2>CO.[Pd]>[ClH:1].[BrH:2].[CH2:8]1[C:9]2[C:4](=[CH:3][CH:12]=[C:11]([NH2:13])[C:10]=2[NH2:16])[CH2:5][CH2:6][NH:7]1

参加物

4

反応物 1

HCID 21253084HCID 21253084、化合物

生成物 1

HCID 21253068HCID 21253068、化合物収率 99%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

The product from Example 5 (7 g) in 250 mL of methanol was treated with 20% Pd/C (1 g) and shaken on a Parr apparatus under a hydrogen atmosphere (50 psi) for 16 h at ambient temperature. The catalyst was removed by filtration and the filtrate evaporated to give the product as a purple solid (6.3 g, 99% yield) that was used immediately without further purification.

後処理

  1. customThe catalyst was removed by filtration
  2. customthe filtrate evaporated

出典と根拠

ORDレコード
ord-9fb7d984c45b417eb7069af3b7ee1949
出典データセット
uspto-grants-2000_05
特許番号
US06057313

反応ノート

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