HCID 21968280、化合物 → HCID 21968279、化合物

HRID 1106508ノート

反応式

HRID 1106508 の反応式
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]2[NH:8][C@@H:7]3[CH2:12][CH2:13][N:14](CC4C=CC=CC=4)[CH2:15][C@H:6]3[C:5]=2[CH:4]=1.[H][H]>CO.[Pd]>[CH3:1][O:2][C:3]1[CH:11]=[CH:10][C:9]2[NH:8][C@@H:7]3[CH2:12][CH2:13][NH:14][CH2:15][C@H:6]3[C:5]=2[CH:4]=1

参加物

5

反応物 2

HCID 21968280HCID 21968280、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 21968279HCID 21968279、化合物収率 78%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of intermediate 8 (11.3 g) in methanol (250 ml) was hydrogenated with palladium-on-carbon (10%, 2 g) as a catalyst. After uptake of hydrogen (1 equivalent), the catalyst was filtered off and the filtrate was evaporated. The residue was solidified in DIPE (30 ml). The precipitate was filtered off and dried, yielding 6.1 g (78%) of (±)-trans-2,3,4,4a,5,9b-hexahydro-8-methoxy-1H-pyrido[4,3-b]indole (intermediate 10).

後処理

  1. customthe filtrate was evaporated
  2. filtrationThe precipitate was filtered off
  3. customdried

出典と根拠

ORDレコード
ord-101d16f8f0d4451f89cd84ce1543db2d
出典データセット
uspto-grants-2000_05
特許番号
US06057325

反応ノート

読み込み中…