Succinic anhydride → (R/S)-1-(1-adamantyl)methyl-2-(2-carboxyethyl)carbonyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole

HRID 1106933

反応式

HRID 1106933 の反応式
[C:1]12([CH2:11][CH:12]3[C:17]4[NH:18][C:19]5[C:24]([C:16]=4[CH2:15][CH2:14][NH:13]3)=[CH:23][CH:22]=[CH:21][CH:20]=5)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[C:25]1(=[O:31])[O:30][C:28](=[O:29])[CH2:27][CH2:26]1>O1CCOCC1>[C:1]12([CH2:11][CH:12]3[C:17]4[NH:18][C:19]5[C:24]([C:16]=4[CH2:15][CH2:14][N:13]3[C:25]([CH2:26][CH2:27][C:28]([OH:30])=[O:29])=[O:31])=[CH:23][CH:22]=[CH:21][CH:20]=5)[CH2:10][CH:5]3[CH2:4][CH:3]([CH2:9][CH:7]([CH2:6]3)[CH2:8]1)[CH2:2]2

参加物

4

反応物 2

HCID 7922Succinic anhydrideHCID 53933490(R/S)-1-(1-adamantyl)methyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole

生成物 1

HCID 53950661(R/S)-1-(1-adamantyl)methyl-2-(2-carboxyethyl)carbonyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A mixture of (R/S)-1-(1-adamantyl)methyl-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole (640 mg, 2.0 mmol) and succinic anhydride (250 mg, 2.5 mmol) was stirred in dioxan (5 ml) at room temperature for 17 hours. The white precipiate which had formed was isolated by filtration, washed with dioxan and dried. (640 mg, 76%).

後処理

  1. customThe white precipiate which had formed
  2. customwas isolated by filtration
  3. washwashed with dioxan
  4. customdried

出典と根拠

ORDレコード
ord-0532127899f14e8aba970fd530a877ab
出典データセット
uspto-grants-2000_05
特許番号
US06057311

関連ノート

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