2-Chlorobenzyl chloride → 2-Chlorobenzyl azide
反応式
[N-:1]=[N+:2]=[N-:3].[Na+].[Cl:5][C:6]1[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=1[CH2:8]Cl>CN(C=O)C>[Cl:5][C:6]1[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=1[CH2:8][N:1]=[N+:2]=[N-:3]参加物
4
実験手順
A cold (0° C.) solution of sodium azide (1.45 g, 22.3 mmol) in 50 ml of DMF was treated with 2-chlorobenzyl chloride (2.4 ml, 18.6 mmol). The reaction mixture was stirred at room temperature for 2 days, under N2 and then partitioned between EtOAc and H2O. The resultant layers were separated and the organic layer was dried over Na2SO4, filtered and then concentrated in vacuo.
後処理
- custompartitioned between EtOAc and H2O
- customThe resultant layers were separated
- dry with materialthe organic layer was dried over Na2SO4
- filtrationfiltered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-2303b028f71242c69a7aa8606e2b1239
- 出典データセット
- uspto-grants-2000_05
- 特許番号
- US06060484
反応ノート
読み込み中…