Sodium Hydroxide → N-(5-dimethylaminomethyl-4,6-dimethylindolin-7-yl)-2,2-dimethylpropanamide

HRID 1107944ノート

反応式

HRID 1107944 の反応式
C([N:4]1[C:12]2[C:7](=[C:8]([CH3:25])[C:9]([CH2:21][N:22]([CH3:24])[CH3:23])=[C:10]([CH3:20])[C:11]=2[NH:13][C:14](=[O:19])[C:15]([CH3:18])([CH3:17])[CH3:16])[CH2:6][CH2:5]1)(=O)C.[OH-].[Na+]>CO.O>[CH3:23][N:22]([CH2:21][C:9]1[C:8]([CH3:25])=[C:7]2[C:12](=[C:11]([NH:13][C:14](=[O:19])[C:15]([CH3:16])([CH3:17])[CH3:18])[C:10]=1[CH3:20])[NH:4][CH2:5][CH2:6]2)[CH3:24]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 22247311N-(1-Acetyl-5-dimethylaminomethyl-4,6-dimethylindolin-7-yl)-2,2-dimethylpropanamide

生成物 1

HCID 22247324N-(5-dimethylaminomethyl-4,6-dimethylindolin-7-yl)-2,2-dimethylpropanamide収率 79.7%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

反応条件

温度
60 °C

実験手順

N-(1-Acetyl-5-dimethylaminomethyl-4,6-dimethylindolin-7-yl)-2,2-dimethylpropanamide (1.0 g) was dissolved in MeOH (10 ml) and a solution of NaOH (580 mg) in water (3 ml) was added, which was followed by stirring at 60° C. for 2 hr. MeOH was evaporated under reduced pressure and CHCl3 (100 ml) was added. The mixture was washed with saturated brine and dried over anhydrous sodium sulfate. CHCl3 was evaporated under reduced pressure to give 700 mg of N-(5-dimethylaminomethyl-4,6-dimethylindolin-7-yl)-2,2-dimethylpropanamide.

後処理

  1. customMeOH was evaporated under reduced pressure and CHCl3 (100 ml)
  2. additionwas added
  3. washThe mixture was washed with saturated brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. customCHCl3 was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-70f88ca1701a4dccae0407b53361037c
出典データセット
uspto-grants-2000_05
特許番号
US06063806

反応ノート

読み込み中…