Trifluoroacetic acid → 4-(4-Bromo-7-methoxybenzofuran-2-ylmethoxy)-piperidine

HRID 1108320ノート

反応式

HRID 1108320 の反応式
FC(F)(F)C(O)=O.C(OC([N:15]1[CH2:20][CH2:19][CH:18]([O:21][CH2:22][C:23]2[O:24][C:25]3[C:31]([O:32][CH3:33])=[CH:30][CH:29]=[C:28]([Br:34])[C:26]=3[CH:27]=2)[CH2:17][CH2:16]1)=O)(C)(C)C>ClCCl>[Br:34][C:28]1[C:26]2[CH:27]=[C:23]([CH2:22][O:21][CH:18]3[CH2:19][CH2:20][NH:15][CH2:16][CH2:17]3)[O:24][C:25]=2[C:31]([O:32][CH3:33])=[CH:30][CH:29]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 540770204-(4-Bromo-7-methoxybenzofuran-2-ylmethoxy)-piperidine-1-carboxylic Acid tert-butyl Ester

生成物 1

HCID 187848694-(4-Bromo-7-methoxybenzofuran-2-ylmethoxy)-piperidine収率 97.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

Trifluoroacetic acid (5 ml) was added to a stirred solution of 4-(4-bromo-7-methoxybenzofuran-2-ylmethoxy)-piperidine-1-carboxylic acid tert-butyl ester (1.3 g) in dichloromethane (50 ml). After stirring at room temperate overnight the reaction was diluted with dichloromethane (150 ml) washed with 1M sodium hydroxide (100 ml) and dried over magnesium sulfate. The organic phase was concentrated in vacuo to afford the title compound as a pale yellow gum (0.98 g).

後処理

  1. washwashed with 1M sodium hydroxide (100 ml)
  2. dry with materialdried over magnesium sulfate
  3. concentrationThe organic phase was concentrated in vacuo

出典と根拠

ORDレコード
ord-ce50eecc609e43c3b6455bd48d38dc13
出典データセット
uspto-grants-2000_05
特許番号
US06066657

反応ノート

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