2-(Methylamino)ethanol → N-2-Hydroxyethyl-N-2-hydroxyoctadecyl-N-methyl amine

HRID 1109

反応式

HRID 1109 の反応式
[O:1]1[CH:3]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[CH2:2]1.[CH3:20][NH:21][CH2:22][CH2:23][OH:24]>C(O)C>[OH:24][CH2:23][CH2:22][N:21]([CH2:2][CH:3]([OH:1])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])[CH3:20]

参加物

4

反応物 2

HCID 80162-(Methylamino)ethanolHCID 238721,2-Epoxyoctadecane

生成物 1

HCID 19694636N-2-Hydroxyethyl-N-2-hydroxyoctadecyl-N-methyl amine収率 67%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
80 °C

実験手順

A 300-ml flask equipped with a stirrer was charged with 26.85 g (0.1 mol) of 1,2-epoxyoctadecane, 7.51 g (0.1 mol) of N-methylethanolamine and 50 ml of ethanol, and the contents were stirred at 80° C. for 18 hours. After the solvent was distilled off under reduced pressure, the resultant residue was purified by column chromatography on silica gel, thereby obtaining 23.0 g (yield: 67%) of the title compound (IIc-2).

後処理

  1. customA 300-ml flask equipped with a stirrer
  2. distillationAfter the solvent was distilled off under reduced pressure
  3. customthe resultant residue was purified by column chromatography on silica gel

出典と根拠

ORDレコード
ord-b816d25167cf4c2ca0b10e123324d743
出典データセット
uspto-grants-1998_03
特許番号
US05723497

関連ノート

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